Standard name GSE20754_WT_VS_TCF1_KO_MEMORY_CD8_TCELL_DN
Systematic name M7782
Brief description Genes down-regulated in memory CD8 T cells: wildtype versus TCF7 [GeneID=6932] knockout.
Full description or abstract TCF-1 is an HMG family transcription factor which is known to be activated by the canonical Wnt signaling pathway and modulated by other signals such as those derived from T cell receptor. We found that during CD8 T cell responses, TCF-1 deficiency impaired long-term maintenance of antigen-specific memory CD8 T cells. We used microarrays to detect gene expression changes in memory CD8 T cells caused by TCF-1 deficiency.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 20727791   Authors: Zhou X,Yu S,Zhao DM,Harty JT,Badovinac VP,Xue HH
Exact source GSE20754_2450_200_DN
Related gene sets (show 1 additional gene sets from the source publication)

(show 77 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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