Human Gene Set: GSE22229_RENAL_TRANSPLANT_IMMUNOSUPP_THERAPY_VS_HEALTHY_PBMC_DN

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Standard name GSE22229_RENAL_TRANSPLANT_IMMUNOSUPP_THERAPY_VS_HEALTHY_PBMC_DN
Systematic name M7479
Brief description Genes down-regulated in periperal blood monocytes (PBMC): kidney transplant recipients receiving immunosuppression therapy versus healthy controls.
Full description or abstract In this study, investigators recruited the largest reported cohort of tolerant kidney transplant recipients who maintained their graft after ceasing to take their immunosuppression drug, and compared this cohort to subjects with stable allograft function while on immunosuppression and healthy non transplated, controls. Using gene expression studies, they identified genetic markers that are strong candidates for predicting kidney transplant candidates who may benefit from minimization or withdrawl of immunosuppression. Microarrays were used to detect expressed gene profiles of whole-blood total RNA from subjects in the tolerant, standard immunotherapy and healthy control participants
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 20501946   Authors: Newell KA,Asare A,Kirk AD,Gisler TD,Bourcier K,Suthanthiran M,Burlingham WJ,Marks WH,Sanz I,Lechler RI,Hernandez-Fuentes MP,Turka LA,Seyfert-Margolis VL,Immune Tolerance Network ST507 Study Group
Exact source GSE22229_2397_200_DN
Related gene sets (show 5 additional gene sets from the source publication)
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Organism Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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