Gene Set: GSE23321_EFFECTOR_MEMORY_VS_NAIVE_CD8_TCELL_UP

Standard name GSE23321_EFFECTOR_MEMORY_VS_NAIVE_CD8_TCELL_UP
Systematic name M8428
Brief description Genes up-regulated in CD8 T cells: effector memory versus na´ve.
Full description or abstract An early-differentiated CD8+ memory T cell subset with stem cell-like properties (TSCM) can be identified within the na´ve-like T cell population by the expression of CD95/Fas. Based on experiments including exon- and gene-level expression analysis, we provide evidence that this subset of antigen-specific cells represents an early precursor of conventional central (TCM) and effector (TEM) memory CD8+ T cells with enhanced self-renewal capacity and proliferative potential. We identified 900 genes differentially expressed between major T cell subsets defined along with memory T cell commitment. Based on the analysis of these genes, CD95+ na´ve T cells (TSCM) cluster closer to the CD8+ T memory compartment than to classical (CD95-) na´ve T (TN) cells, and display an intermittent phenotype between classical TN and TCM cells in terms of all major T cell differentiation markers analyzed.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 21926977   Authors: Gattinoni L,Lugli E,Ji Y,Pos Z,Paulos CM,Quigley MF,Almeida JR,Gostick E,Yu Z,Carpenito C,Wang E,Douek DC,Price DA,June CH,Marincola FM,Roederer M,Restifo NP
Exact source GSE23321_2650_200_UP
Related gene sets (show 11 additional gene sets from the source publication)

(show 68 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 196 genes
Gene families Categorize these 196 genes by gene family
Show members (show 200 members mapped to 196 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.