Gene Set: GSE24972_WT_VS_IRF8_KO_MARGINAL_ZONE_SPLEEN_BCELL_DN

Standard name GSE24972_WT_VS_IRF8_KO_MARGINAL_ZONE_SPLEEN_BCELL_DN
Systematic name M8094
Brief description Genes down-regulated in spleen marginal zone B lymphocytes: wildtype versus IRF8 [GeneID=3394] knockout.
Full description or abstract Conditional IRF8 KO mice (mice with a conditional allele of Irf8 crossed with CD19-Cre mice) showed increased numbers of both Gene expression data spleen marginal zone (MZ) and Gene expression data spleen follicular (FO) B cells compared to control mice. To evaluate gene expression patterns that distinguished FO or MZ B cells derived from conditional KO and control mice, we used Affymetrix GeneChip® Mouse gene 1.0 ST Array.
Collection C7: immunologic signature gene sets
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Source publication Pubmed 21178004   Authors: Feng J,Wang H,Shin DM,Masiuk M,Qi CF,Morse HC
Exact source GSE24972_2962_200_DN
Related gene sets (show 7 additional gene sets from the source publication)

(show 26 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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