Gene Set: GSE30083_SP3_VS_SP4_THYMOCYTE_DN

Standard name GSE30083_SP3_VS_SP4_THYMOCYTE_DN
Systematic name M5037
Brief description Genes down-regulated in comparison of SP3 thymocytes versus SP4 thymocytes.
Full description or abstract After positive selection in the thymus, the newly generated single positive (SP) thymocytes are phenotypically and functionally immature and undergo apoptosis upon antigen stimulation. In the thymic medullary microenvironment, SP cells progressively acquire immunocompetence. Negative selection to remove autoreactive T cells also occur at this stage. We have defined four subsets of CD4 SP, namely, SP1, SP2, SP3, and SP4 that follow a functional maturation program and a sequential emergence during mouse ontogeny.We used microarray to detail the global programm of gene expression during the maturation of murine CD4 single positive thymocytes
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 22022412   Authors: Teng F,Zhou Y,Jin R,Chen Y,Pei X,Liu Y,Dong J,Wang W,Pang X,Qian X,Chen WF,Zhang Y,Ge Q.
Exact source GSE30083_2165_200_DN
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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