Systematic name M8768
Brief description Genes down-regulated in dendritic cells with knockout of NLRP10 [GeneID=338322]: control versus LPS.
Full description or abstract Nlrp10-deficient mice have a profound defect in helper T cell-driven immune responses. T cell priming is impaired due to a defect in the emigration of a dendritic cells from inflamed tissue and antigen transport to draining lymph nodes. DC chemotaxis to CCR7-dependent and independent ligands is intact in the absence of Nlrp10. Therefore to identify novel molecules potentially involved in Nlrp10-dependent DC function we used an unbiased gene array approach on Nlrp10-deficient BMDCs treated with or without LPS.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 22538615   Authors: Eisenbarth SC,Williams A,Colegio OR,Meng H,Strowig T,Rongvaux A,Henao-Mejia J,Thaiss CA,Joly S,Gonzalez DG,Xu L,Zenewicz LA,Haberman AM,Elinav E,Kleinstein SH,Sutterwala FS,Flavell RA
Exact source GSE36009_2674_200_DN
Related gene sets (show 7 additional gene sets from the source publication)

(show 47 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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