Human Gene Set: GSE360_DC_VS_MAC_B_MALAYI_HIGH_DOSE_DN


Standard name GSE360_DC_VS_MAC_B_MALAYI_HIGH_DOSE_DN
Systematic name M5186
Brief description Genes down-regulated in comparison of dendritic cells (DC) exposed to 50 worm/well B. malayi versus macrophages exposed to 50 worms/well B. malayi.
Full description or abstract Monocyte-derived dendritic cells (DC) and macrophages (M?) generated in vitro from the same individual blood donors were exposed to five different pathogens, and gene expression profiles were assessed by microarray analysis. Responses to Mycobacterium tuberculosis and to phylogenetically distinct protozoan (Leishmania major, L. donovani, Toxoplasma gondii) and helminth (Brugia malayi) parasites were examined, each of which produces chronic infections in humans yet vary considerably in the nature of the immune responses they trigger.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 12663451   Authors: Chaussabel D,Semnani RT,McDowell MA,Sacks D,Sher A,Nutman TB
Exact source GSE360_1017_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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