Gene Set: GSE360_T_GONDII_VS_B_MALAYI_LOW_DOSE_MAC_DN

Standard name GSE360_T_GONDII_VS_B_MALAYI_LOW_DOSE_MAC_DN
Systematic name M5257
Brief description Genes down-regulated in comparison of macrophages exposed to T. gondii versus macrophages exposed to 5 worms/well B. malayi.
Full description or abstract Monocyte-derived dendritic cells (DC) and macrophages (M?) generated in vitro from the same individual blood donors were exposed to five different pathogens, and gene expression profiles were assessed by microarray analysis. Responses to Mycobacterium tuberculosis and to phylogenetically distinct protozoan (Leishmania major, L. donovani, Toxoplasma gondii) and helminth (Brugia malayi) parasites were examined, each of which produces chronic infections in humans yet vary considerably in the nature of the immune responses they trigger.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 12663451   Authors: Chaussabel D,Semnani RT,McDowell MA,Sacks D,Sher A,Nutman TB.
Exact source GSE360_1045_200_DN
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Organism Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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