Gene Set: GSE37534_GW1929_VS_ROSIGLITAZONE_TREATED_CD4_TCELL_PPARG1_FOXP3_TRANSDUCED_DN

Standard name GSE37534_GW1929_VS_ROSIGLITAZONE_TREATED_CD4_TCELL_PPARG1_FOXP3_TRANSDUCED_DN
Systematic name M8989
Brief description Genes down-regulated in CD4 [GeneID=920] T cells over-expressing FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468]: GW1929 [PubChem=6518171] versus rosiglitazone [PubChem=77999].
Full description or abstract Pioglitazone treatment of CD4+FoxP3- T cells transduced with Pparg and Foxp3 up-regulated a set of genes whose products have been implicated in lipid metabolism pathways. To verify the specificity of this treatment, we performed microarray analysis on Foxp3+Pparg1-transduced CD4+FoxP3- T cells after treatment with other PPARg agonists such as Rosiglitazone (TZD) and GW1929 (non-TZD).
Collection C7: immunologic signature gene sets
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Source publication Pubmed 22722857   Authors: Cipolletta D,Feuerer M,Li A,Kamei N,Lee J,Shoelson SE,Benoist C,Mathis D
Exact source GSE37534_2868_200_DN
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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