Human Gene Set: GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_IL23A_TREATED_CD4_TCELL_DN


Standard name GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_IL23A_TREATED_CD4_TCELL_DN
Systematic name M5629
Brief description Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with TGFB1 [GeneID=7040] versus those treated with TGFB3 [GeneID=7043] treated with IL6 [GeneID=3569] and IL23A [GeneID=51561].
Full description or abstract TGF-beta3 produced by developing Th17 cells induces highly pathogenic T cells that are functionally and molecularly distinct from TGF-beta1-induced Th17 cells. The microarray data represent a distinct molecular signature for pathogenic versus non-pathogenic Th17 cells.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 22961052   Authors: Lee Y,Awasthi A,Yosef N,Quintana FJ,Xiao S,Peters A,Wu C,Kleinewietfeld M,Kunder S,Hafler DA,Sobel RA,Regev A,Kuchroo VK
Exact source GSE39820_1565_200_DN
Related gene sets (show 21 additional gene sets from the source publication)

(show 390 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 199 genes
Gene families ? Categorize these 199 genes by gene family
Show members (show 200 source identifiers mapped to 199 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

A big thank you to everyone who responded to our request for emails of support for our grant application resubmission.
Reading them made us feel so appreciated and valued by all of you.

We hope we can continue to bring you GSEA/MSigDB in the years to come.
-The GSEA/MSigDB Team


See MSigDB license terms here. Please note that certain gene sets have special access terms.