Gene Set: GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN

Standard name GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN
Systematic name M5991
Brief description Genes down-regulated in macrophages: wildtype versus SOCS3 [GeneID=9021].
Full description or abstract Effects of SOCS3 on the transcriptional response of bone marrow-derived macrophages to IL-6. Fetal liver cells from SOCS3+/+ or SOCS3-/- embryos were used to reconstitute recipient mice. Donor derived bone marrow from these mice was differentiated to macrophages. Macrophages were either unstimulated, or stimulated for 100 or 400 minutes with 10 ng/ml IL-6.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 12754506   Authors: Lang R,Pauleau AL,Parganas E,Takahashi Y,Mages J,Ihle JN,Rutschman R,Murray PJ
Exact source GSE411_2906_200_DN
Related gene sets (show 17 additional gene sets from the source publication)

(show 191 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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