Gene Set: GSE4142_PLASMA_CELL_VS_GC_BCELL_DN

Standard name GSE4142_PLASMA_CELL_VS_GC_BCELL_DN
Systematic name M6385
Brief description Genes down-regulated in plasma cells versus germinal center B lymphocytes.
Full description or abstract In order to better understand the factors that regulate B cell differentiation upon exposure to antigen, we compares global gene expression profiles from naive B cells with antigen-specific plasma, germinal center, and memory B cells after immunization with the T-dependent antigen, NP-CGG. The memory B cell-enriched transcripts were then compared with memory T cell-enriched and hematopoietic stem cell-enriched transcripts in order to generate a transcriptional profile of self-renewal within the hematopoietic system.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 16492737   Authors: Luckey CJ,Bhattacharya D,Goldrath AW,Weissman IL,Benoist C,Mathis D
Exact source GSE4142_3225_200_DN
Related gene sets (show 17 additional gene sets from the source publication)

(show 358 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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