Gene Set: GSE42021_CD24HI_VS_CD24LOW_TREG_THYMUS_DN

Standard name GSE42021_CD24HI_VS_CD24LOW_TREG_THYMUS_DN
Systematic name M9588
Brief description Genes down-regulated in thymic T reg: CD24 high [GeneID=100133941] versus CD24 low [GeneID=100133941].
Full description or abstract We investigated at which stage of maturation commitment to a stable Foxp3-expressing phenotype takes place. We assessed stability of Foxp3 expression in thymic Foxp3+ Treg subsets of different maturity, defined by CD24 expression. Next we compared gene expression profiles of Foxp3+ Treg subsets (+) of different maturity (24lo, 24int, 24hi) and could identify a set of genes that were specifically up or downregulated in Foxp3+ Tregs, but not in Foxp3- conventional T cells, in a maturation-dependent manner.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 23420886   Authors: Toker A,Engelbert D,Garg G,Polansky JK,Floess S,Miyao T,Baron U,Düber S,Geffers R,Giehr P,Schallenberg S,Kretschmer K,Olek S,Walter J,Weiss S,Hori S,Hamann A,Huehn J
Exact source GSE42021_3788_200_DN
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(show 70 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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