Human Gene Set: GSE42021_TREG_PLN_VS_TREG_PRECURSORS_THYMUS_UP


Standard name GSE42021_TREG_PLN_VS_TREG_PRECURSORS_THYMUS_UP
Systematic name M9569
Brief description Genes up-regulated in T reg from: peripheral lymph nodes versus thymic precursors.
Full description or abstract We investigated at which stage of maturation commitment to a stable Foxp3-expressing phenotype takes place. We assessed stability of Foxp3 expression in thymic Foxp3+ Treg subsets of different maturity, defined by CD24 expression. Next we compared gene expression profiles of Foxp3+ Treg subsets (+) of different maturity (24lo, 24int, 24hi) and could identify a set of genes that were specifically up or downregulated in Foxp3+ Tregs, but not in Foxp3- conventional T cells, in a maturation-dependent manner.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 23420886   Authors: Toker A,Engelbert D,Garg G,Polansky JK,Floess S,Miyao T,Baron U,Düber S,Geffers R,Giehr P,Schallenberg S,Kretschmer K,Olek S,Walter J,Weiss S,Hori S,Hamann A,Huehn J
Exact source GSE42021_3779_200_UP
Related gene sets (show 35 additional gene sets from the source publication)

(show 70 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 197 genes
Gene families ? Categorize these 197 genes by gene family
Show members (show 200 source identifiers mapped to 197 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.