Gene Set: GSE44732_UNSTIM_VS_IL27_STIM_IMATURE_DC_UP

Standard name GSE44732_UNSTIM_VS_IL27_STIM_IMATURE_DC_UP
Systematic name M9699
Brief description Genes up-regulated in immature dendritic cells: untreated versus IL27 [GeneID=246778].
Full description or abstract IL-27 treated DCs were shown to be highly potent inhibitors of cis HIV-1, particularly of CCR5 tropic strains. Microarray studies of IL-27 treated DCs showed no up-regulation of Type I (IFN) gene expression. Neutralization of the Type-I IFN receptor had no impact on the HIV inhibition. Lastly, IL-27 mediated inhibition was shown to act post-viral entry and prior to completion of reverse transcription. These results show for the first time that IL-27 is a potent inhibitor of cis HIV-1 infection in DCs by a Type I IFN independent mechanism.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 23527130   Authors: Chen Q,Swaminathan S,Yang D,Dai L,Sui H,Yang J,Hornung RL,Wang Y,Huang W da,Hu X,Lempicki RA,Imamichi T
Exact source GSE44732_3800_200_UP
Related gene sets (show 1 additional gene sets from the source publication)

(show 193 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 200 genes
Gene families Categorize these 200 genes by gene family
Show members (show 200 members mapped to 200 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.