Gene Set: GSE7459_UNTREATED_VS_IL6_TREATED_ACT_CD4_TCELL_DN

Standard name GSE7459_UNTREATED_VS_IL6_TREATED_ACT_CD4_TCELL_DN
Systematic name M463
Brief description Genes down-regulated in CD4 [GeneID=920] T cells: control versus IL6 [GeneID=3569].
Full description or abstract IL-6, a proinflammtory cytokine produced by antigen presenting cells and non-hematopoietic cells in response to external stimuli, acts as an important bridge between the innate and adaptive immune responses. IL-6 together with IL-4 can promote Th2 polarization, while in combination with TGFbeta mediates Th17 differentiation. We examined early changes in gene expression in mouse CD4+ T cells induced by IL-6.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 19139170   Authors: Dienz O,Eaton SM,Bond JP,Neveu W,Moquin D,Noubade R,Briso EM,Charland C,Leonard WJ,Ciliberto G,Teuscher C,Haynes L,Rincon M
Exact source GSE7459_2237_200_DN
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(show 38 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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