Standard name GSE7831_UNSTIM_VS_CPG_STIM_PDC_1H_UP
Systematic name M6944
Brief description Genes up-regulated in plasmacytoit dendritic cells (1h): untreated versus CpG oligodeoxynucleotide 1826.
Full description or abstract CpG 1826 binds to Toll-like receptor (TLR)9, whereas influenza virus PR8 activates pDC via TLR7. Differential stimulation of pDCs is expected to result in unique activation mechanism(s) leading to a different phenotypically and functionally matured pDC We used microarrays to detail the global programme of gene expression underlying the maturation process of pDC activated with CpG 1826 and influenza virus PR8. We identified a distinct expression profile of upregulated immunomediators.
Collection C7: immunologic signature gene sets
      IMMUNESIGDB: ImmuneSigDB gene sets
Source publication Pubmed 18029397   Authors: Iparraguirre A,Tobias JW,Hensley SE,Masek KS,Cavanagh LL,Rendl M,Hunter CA,Ertl HC,Andrian von UH,Weninger W
Exact source GSE7831_3531_200_UP
Related gene sets (show 15 additional gene sets from the source publication)

(show 26 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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