Gene Set: GSE9650_NAIVE_VS_EFF_CD8_TCELL_DN

Standard name GSE9650_NAIVE_VS_EFF_CD8_TCELL_DN
Systematic name M5820
Brief description Genes down-regulated in comparison of naive CD8 T cells versus effector CD8 T cells.
Full description or abstract CD8 T cells normally differentiate from resting na´ve T cells into function effector and then memory CD8 T cells following acute infections. During chronic viral infections, however, virus-specific CD8 T cells often become exhausted. We used microarrays to examine the gene expression differences between naive, effector, memory and exhausted virus-specific CD8 T cells following lymphocytic choriomeningitis virus infection.
Collection C7: immunologic signature gene sets
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Source publication Pubmed 17950003   Authors: Wherry EJ,Ha SJ,Kaech SM,Haining WN,Sarkar S,Kalia V,Subramaniam S,Blattman JN,Barber DL,Ahmed R.
Exact source GSE9650_1253_200_DN
Related gene sets (show 13 additional gene sets from the source publication)

(show 198 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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