Gene Set: HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_UP

Standard name HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_UP
Systematic name M2553
Brief description Genes distinguishing asparaginase resistant and sensitive B-lineage ALL; here - genes up-regulated in the drug resistant samples.
Full description or abstract Childhood acute lymphoblastic leukemia (ALL) is curable with chemotherapy in approximately 80 percent of patients. However, the cause of treatment failure in the remaining 20 percent of patients is largely unknown.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15295046   Authors: Holleman A,Cheok MH,den Boer ML,Yang W,Veerman AJ,Kazemier KM,Pei D,Cheng C,Pui CH,Relling MV,Janka-Schaub GE,Pieters R,Evans WE
Exact source Fig. 7S: R/S ratio > 1
Related gene sets (show 15 additional gene sets from the source publication)

(show 28 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform AFFY_HG_U133
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Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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