Gene Set: HSIAO_LIVER_SPECIFIC_GENES

Standard name HSIAO_LIVER_SPECIFIC_GENES
Systematic name M13283
Brief description Liver selective genes
Full description or abstract This study creates a compendium of gene expression in normal human tissues suitable as a reference for defining basic organ systems biology. Using oligonucleotide microarrays, we analyze 59 samples representing 19 distinct tissue types. Of approximately 7,000 genes analyzed, 451 genes are expressed in all tissue types and designated as housekeeping genes. These genes display significant variation in expression levels among tissues and are sufficient for discerning tissue-specific expression signatures, indicative of fundamental differences in biochemical processes. In addition, subsets of tissue-selective genes are identified that define key biological processes characterizing each organ. This compendium highlights similarities and differences among organ systems and different individuals and also provides a publicly available resource (Human Gene Expression Index, the HuGE Index, http://www.hugeindex.org) for future studies of pathophysiology.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 11773596   Authors: Hsiao LL,Dangond F,Yoshida T,Hong R,Jensen RV,Misra J,Dillon W,Lee KF,Clark KE,Haverty P,Weng Z,Mutter GL,Frosch MP,Macdonald ME,Milford EL,Crum CP,Bueno R,Pratt RE,Mahadevappa M,Warrington JA,Stephanopoulos G,Gullans SR
Exact source Supplement 3c
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(show 48 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform AFFY_HuGene
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: Renamed from HSIAO_LIVER_SPECIFIC_GENES

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