Gene Set: KAAB_FAILED_HEART_VENTRICLE_DN

Standard name KAAB_FAILED_HEART_VENTRICLE_DN
Systematic name M15188
Brief description Genes down-regulated in the ventricles of failing hearts (DCM and ICM) compared to the healthy controls.
Full description or abstract To obtain region- and disease-specific transcription profiles of human myocardial tissue, we explored mRNA expression from all four chambers of eight explanted failing [idiopathic dilated cardiomyopathy (DCM), n=5; ischemic cardiomyopathy (ICM), n=3], and five non-failing hearts using high-density oligonucleotide arrays (Affymetrix U95Av2). We performed pair-wise comparisons of gene expression in the categories (1) atria versus ventricles, (2) disease-regulated genes in atria and (3) disease-regulated genes in ventricles. In the 51 heart samples examined, 549 genes showed divergent distribution between atria and ventricles (272 genes with higher expression in atria, 277 genes with higher expression in ventricles). Two hundred and eighty-eight genes were differentially expressed in failing myocardium compared to non-failing hearts (19 genes regulated in atria and ventricles, 172 regulated in atria only, 97 genes regulated in ventricles only). For disease-regulated genes, down-regulation was 4.5-times more common than up-regulation. Functional classification according to Gene Ontology identified specific biological patterns for differentially expressed genes. Eleven genes were validated by RT-PCR showing a good correlation with the microarray data. Our goal was to determine a gene expression fingerprint of the heart, accounting for region- and disease-specific aspects. Recognizing common gene expression patterns in heart failure will significantly contribute to the understanding of heart failure and may eventually lead to the development of pathway-specific therapies.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15103417   Authors: Kääb S,Barth AS,Margerie D,Dugas M,Gebauer M,Zwermann L,Merk S,Pfeufer A,Steinmeyer K,Bleich M,Kreuzer E,Steinbeck G,Näbauer M
Exact source Table 3aS, 3bS: CMP ventricle = DOWN
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Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform AFFY_HG_U95
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Version history 3.0: Renamed from HEARTFAILURE_VENTRICLE_DN

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