Standard name KANG_GLIS3_TARGETS
Systematic name M2460
Brief description Genes downregulated in the postnatal day 3 pancreata with impaired function of GLIS3 [GeneID=169792].
Full description or abstract Chromatin assembly factor 1 (CAF-1) deposits histones H3 and H4 rapidly behind replication forks through an interaction with the proliferating cell nuclear antigen (PCNA), a DNA polymerase processivity factor that also binds to a number of replication enzymes and other proteins that act on nascent DNA. The mechanisms that enable CAF-1 and other PCNA-binding proteins to function harmoniously at the replication fork are poorly understood. Here we report that the large subunit of human CAF-1 (p150) contains two distinct PCNA interaction peptides (PIPs). The N-terminal PIP binds strongly to PCNA in vitro but, surprisingly, is dispensable for nucleosome assembly and only makes a modest contribution to targeting p150 to DNA replication foci in vivo. In contrast, the internal PIP (PIP2) lacks one of the highly conserved residues of canonical PIPs and binds weakly to PCNA. Surprisingly, PIP2 is essential for nucleosome assembly during DNA replication in vitro and plays a major role in targeting p150 to sites of DNA replication. Unlike canonical PIPs, such as that of p21, the two p150 PIPs are capable of preferentially inhibiting nucleosome assembly, rather than DNA synthesis, suggesting that intrinsic features of these peptides are part of the mechanism that enables CAF-1 to function behind replication forks without interfering with other PCNA-mediated processes.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 19805515   Authors: Kang HS,Kim YS,ZeRuth G,Beak JY,Gerrish K,Kilic G,Sosa-Pineda B,Jensen J,Pierreux CE,Lemaigre FP,Foley J,Jetten AM
Exact source Table 2
Related gene sets (show 15 gene sets from the same authors)
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Organism Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
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NCI-60 cell lines (National Cancer Institute)
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Version history 5.2: Renamed from ROLEF_GLIS3_TARGETS

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