Human Gene Set: KIM_GASTRIC_CANCER_CHEMOSENSITIVITY


Standard name KIM_GASTRIC_CANCER_CHEMOSENSITIVITY
Systematic name M14702
Brief description Genes up-regulated in gastric cancer patients refractory to chemotherapy treatment with 5-fluorouracil and cisplatin [PubChem=3385;2767] compared to the sensitive state.
Full description or abstract The mechanisms of intrinsic and/or acquired anti-cancer drug resistance have been described in in vitro resistance models, but the clinical relevance has remained undefined. We undertook a prospective study to identify correlations between gene expression and clinical resistance to 5-FU/cisplatin. We compared expression profiles from gastric cancer endoscopic biopsy specimens obtained at a chemosensitive state (partial remission after 5-FU/cisplatin) with those obtained at a refractory state (disease progression), using Affymetrix oligonucleotide microarray technology (U133A). Using 119 discriminating probes and a cross-validation approach, we were able to correctly identify the chemo-responsiveness of 7 pairs of training samples and 1 independent test pair. These exploratory data demonstrate that the gene expression profiles differ between chemosensitive and refractory state gastric cancer biopsy samples.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15033468   Authors: Kim HK,Choi IJ,Kim HS,Kim JH,Kim E,Park IS,Chun JH,Kim IH,Kim IJ,Kang HC,Park JH,Bae JM,Lee JS,Park JG
Exact source Fig 4A
Related gene sets (show 48 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by John Newman (University of Washington)
Source platform or
identifier namespace		 AFFY_HG_U133
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 94 genes
Gene families ? Categorize these 94 genes by gene family
Show members (show 110 source identifiers mapped to 94 genes)
Version history 3.0: Renamed from REFRACTORY_GASTRIC_UP

See MSigDB license terms here. Please note that certain gene sets have special access terms.