Gene Set: KUMAR_PATHOGEN_LOAD_BY_MACROPHAGES

Standard name KUMAR_PATHOGEN_LOAD_BY_MACROPHAGES
Systematic name M2538
Brief description Genes indentified by RNAi screen as regulating infection of THP-1 cells (macrophage) with Mycobacterium tuberculosis.
Full description or abstract We performed a genome-wide siRNA screen to identify host factors that regulated pathogen load in human macrophages infected with a virulent strain of Mycobacterium tuberculosis. Iterative rounds of confirmation, followed by validation, identified 275 such molecules that were all found to functionally associate with each other through a dense network of interactions. This network then yielded to a molecular description of the host cell functional modules that were both engaged and perturbed by the pathogen. Importantly, a subscreen against a panel of field isolates revealed that the molecular composition of the host interface varied with both genotype and the phenotypic properties of the pathogen. An analysis of these differences, however, permitted identification of those host factors that were invariantly involved, regardless of the diversification in adaptive mechanisms employed by the pathogen. Interestingly, these factors were found to predominantly function through the regulation of autophagy.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 20211141   Authors: Kumar D,Nath L,Kamal MA,Varshney A,Jain A,Singh S,Rao KV
Exact source Table 1BS
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Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform Human_NCBI_Gene_ID
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Global Cancer Map (Broad Institute)
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Version history 3.1: First introduced

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