Gene Set: LEE_AGING_MUSCLE_UP

Standard name LEE_AGING_MUSCLE_UP
Systematic name M1658
Brief description Upregulated in the gastrocnemius muscle of aged adult mice (30-month) vs young adult (5-month)
Full description or abstract The gene expression profile of the aging process was analyzed in skeletal muscle of mice. Use of high-density oligonucleotide arrays representing 6347 genes revealed that aging resulted in a differential gene expression pattern indicative of a marked stress response and lower expression of metabolic and biosynthetic genes. Most alterations were either completely or partially prevented by caloric restriction, the only intervention known to retard aging in mammals. Transcriptional patterns of calorie-restricted animals suggest that caloric restriction retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 10464095   Authors: Lee CK,Klopp RG,Weindruch R,Prolla TA
Exact source Table 1S
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(show 10 gene sets from the same authors)
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Organism Mus musculus
Contributed by John Newman (University of Washington)
Source platform MOUSE_SEQ_ACCESSION
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Version history 3.1: First introduced

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