Gene Set: LEE_LIVER_CANCER_HEPATOBLAST

Standard name LEE_LIVER_CANCER_HEPATOBLAST
Systematic name M13123
Brief description Fig.5, Supplementary Fig.2 Genes overexpressed in human hepatocellular carcinoma with hepatoblast property
Full description or abstract The variability in the prognosis of individuals with hepatocellular carcinoma (HCC) suggests that HCC may comprise several distinct biological phenotypes. These phenotypes may result from activation of different oncogenic pathways during tumorigenesis and/or from a different cell of origin. Here we address whether the transcriptional characteristics of HCC can provide insight into the cellular origin of the tumor. We integrated gene expression data from rat fetal hepatoblasts and adult hepatocytes with HCC from human and mouse models. Individuals with HCC who shared a gene expression pattern with fetal hepatoblasts had a poor prognosis. The gene expression program that distinguished this subtype from other types of HCC included markers of hepatic oval cells, suggesting that HCC of this subtype may arise from hepatic progenitor cells. Analyses of gene networks showed that activation of AP-1 transcription factors in this newly identified HCC subtype might have key roles in tumor development.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 16532004   Authors: Lee JS,Heo J,Libbrecht L,Chu IS,Kaposi-Novak P,Calvisi DF,Mikaelyan A,Roberts LR,Demetris AJ,Sun Z,Nevens F,Roskams T,Thorgeirsson SS
Exact source Fig.5
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Organism Homo sapiens
Contributed by Yujin Hoshida (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 3.0: First introduced

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