Gene Set: LEE_LIVER_CANCER_SURVIVAL_DN

Standard name LEE_LIVER_CANCER_SURVIVAL_DN
Systematic name M7987
Brief description Genes highly expressed in hepatocellular carcinoma with poor survival.
Full description or abstract We analyzed global gene expression patterns of 91 human hepatocellular carcinomas (HCCs) to define the molecular characteristics of the tumors and to test the prognostic value of the expression profiles. Unsupervised classification methods revealed two distinctive subclasses of HCC that are highly associated with patient survival. This association was validated via 5 independent supervised learning methods. We also identified the genes most strongly associated with survival by using the Cox proportional hazards survival analysis. This approach identified a limited number of genes that accurately predicted the length of survival and provides new molecular insight into the pathogenesis of HCC. Tumors from the low survival subclass have strong cell proliferation and antiapoptosis gene expression signatures. In addition, the low survival subclass displayed higher expression of genes involved in ubiquitination and histone modification, suggesting an etiological involvement of these processes in accelerating the progression of HCC. In conclusion, the biological differences identified in the HCC subclasses should provide an attractive source for the development of therapeutic targets (e.g., HIF1a) for selective treatment of HCC patients. Supplementary material for this article can be found on the HEPATOLOGY Web site (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15349906   Authors: Lee JS,Chu IS,Heo J,Calvisi DF,Sun Z,Roskams T,Durnez A,Demetris AJ,Thorgeirsson SS
Exact source Table 1S
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Organism Homo sapiens
Contributed by Yujin Hoshida (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 3.0: First introduced

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