Systematic name M1712
Brief description Genes enriched in neurons in the adult mouse brain identified through correlation-based searches seeded with neuron cell-type specific gene expression patterns.
Full description or abstract Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the nervous system. We describe here an anatomically comprehensive digital atlas containing the expression patterns of approximately 20,000 genes in the adult mouse brain. Data were generated using automated high-throughput procedures for in situ hybridization and data acquisition, and are publicly accessible online. Newly developed image-based informatics tools allow global genome-scale structural analysis and cross-correlation, as well as identification of regionally enriched genes. Unbiased fine-resolution analysis has identified highly specific cellular markers as well as extensive evidence of cellular heterogeneity not evident in classical neuroanatomical atlases. This highly standardized atlas provides an open, primary data resource for a wide variety of further studies concerning brain organization and function.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 17151600   Authors: Lein ES,Hawrylycz MJ,Ao N,Ayres M,Bensinger A,Bernard A,Boe AF,Boguski MS,Brockway KS,Byrnes EJ,Chen L,Chen TM,Chin MC,Chong J,Crook BE,Czaplinska A,Dang CN,Datta S,Dee NR,Desaki AL,Desta T,Diep E,Dolbeare TA,Donelan MJ,Dong HW,Dougherty JG,Duncan BJ,Ebbert AJ,Eichele G,Estin LK,Faber C,Facer BA,Fields R,Fischer SR,Fliss TP,Frensley C,Gates SN,Glattfelder KJ,Halverson KR,Hart MR,Hohmann JG,Howell MP,Jeung DP,Johnson RA,Karr PT,Kawal R,Kidney JM,Knapik RH,Kuan CL,Lake JH,Laramee AR,Larsen KD,Lau C,Lemon TA,Liang AJ,Liu Y,Luong LT,Michaels J,Morgan JJ,Morgan RJ,Mortrud MT,Mosqueda NF,Ng LL,Ng R,Orta GJ,Overly CC,Pak TH,Parry SE,Pathak SD,Pearson OC,Puchalski RB,Riley ZL,Rockett HR,Rowland SA,Royall JJ,Ruiz MJ,Sarno NR,Schaffnit K,Shapovalova NV,Sivisay T,Slaughterbeck CR,Smith SC,Smith KA,Smith BI,Sodt AJ,Stewart NN,Stumpf KR,Sunkin SM,Sutram M,Tam A,Teemer CD,Thaller C,Thompson CL,Varnam LR,Visel A,Whitlock RM,Wohnoutka PE,Wolkey CK,Wong VY,Wood M,Yaylaoglu MB,Young RC,Youngstrom BL,Yuan XF,Zhang B,Zwingman TA,Jones AR
Exact source Table 1S: neuron-enriched
Related gene sets (show 9 additional gene sets from the source publication)

(show 120 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
Source platform MOUSE_GENE_SYMBOL
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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