Gene Set: LIN_NPAS4_TARGETS_UP

Standard name LIN_NPAS4_TARGETS_UP
Systematic name M687
Brief description Genes up-regulated in neurons after NPAS4 [GeneID=266743] knockdown by RNAi.
Full description or abstract Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity-dependent development of GABA (gamma-aminobutyric acid)-releasing inhibitory synapses. Here we report the identification of a transcription factor, Npas4, that plays a role in the development of inhibitory synapses by regulating the expression of activity-dependent genes, which in turn control the number of GABA-releasing synapses that form on excitatory neurons. These findings demonstrate that the activity-dependent gene program regulates inhibitory synapse development, and suggest a new role for this program in controlling the homeostatic balance between synaptic excitation and inhibition.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18815592   Authors: Lin Y,Bloodgood BL,Hauser JL,Lapan AD,Koon AC,Kim TK,Hu LS,Malik AN,Greenberg ME
Exact source Table 1S: U = Up-regulated
Related gene sets (show 1 additional gene sets from the source publication)

(show 19 gene sets from the same authors)
External links  
Filtered by similarity
Organism Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
Source platform AFFY_Mouse430
Dataset references (show 3 datasets)
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 170 genes
Gene families Categorize these 170 genes by gene family
Show members (show 238 members mapped to 170 genes)
Version history 3.0: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.