Gene Set: LI_WILMS_TUMOR_ANAPLASTIC_UP

Standard name LI_WILMS_TUMOR_ANAPLASTIC_UP
Systematic name M1215
Brief description Selected up-regulated genes distinguishing between Wilms tumors of different histological types: anaplastic vs favorable histology.
Full description or abstract Anaplasia (unfavorable histology) is associated with therapy resistance and poor prognosis of Wilms tumor, but the molecular basis for this phenotype is unclear. Here, we used a cDNA array with 9240 clones relevant to cancer biology and/or kidney development to examine the expression profiles of 54 Wilms tumors, five normal kidneys and fetal kidney. By linking genes differentially expressed between fetal kidney and Wilms tumors to kidney morphogenesis, we found that genes expressed at a higher level in Wilms tumors tend to be expressed more in uninduced metanephrogenic mesenchyme or blastema than in their differentiated structures. Conversely, genes expressed at a lower level in Wilms tumors tend to be expressed less in uninduced metanephrogenic mesenchyme or blastema. We also identified 97 clones representing 76 Unigenes or unclustered ESTs that clearly separate anaplastic Wilms tumors from tumors with favorable histology. Genes in this set provide insight into the nature of the abnormal nuclear morphology of anaplastic tumors and may facilitate identification of molecular targets to improve their responsiveness to treatment.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15531917   Authors: Li W,Kessler P,Williams BR
Exact source Table 2: change > 0
Related gene sets (show 3 additional gene sets from the source publication)

(show 327 gene sets from the same authors)
External links  
Organism Homo sapiens
Contributed by Leona Saunders (MSigDB Team)
Source platform HUMAN_SEQ_ACCESSION
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 17 genes
Gene families Categorize these 17 genes by gene family
Show members (show 20 members mapped to 17 genes)
Version history 3.1: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.