Gene Set: LU_AGING_BRAIN_DN

Standard name LU_AGING_BRAIN_DN
Systematic name M9112
Brief description Age down-regulated genes in the human frontal cortex.
Full description or abstract The ageing of the human brain is a cause of cognitive decline in the elderly and the major risk factor for Alzheimer's disease. The time in life when brain ageing begins is undefined. Here we show that transcriptional profiling of the human frontal cortex from individuals ranging from 26 to 106 years of age defines a set of genes with reduced expression after age 40. These genes play central roles in synaptic plasticity, vesicular transport and mitochondrial function. This is followed by induction of stress response, antioxidant and DNA repair genes. DNA damage is markedly increased in the promoters of genes with reduced expression in the aged cortex. Moreover, these gene promoters are selectively damaged by oxidative stress in cultured human neurons, and show reduced base-excision DNA repair. Thus, DNA damage may reduce the expression of selectively vulnerable genes involved in learning, memory and neuronal survival, initiating a programme of brain ageing that starts early in adult life.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15190254   Authors: Lu T,Pan Y,Kao SY,Li C,Kohane I,Chan J,Yankner BA
Exact source Table 2S: Fold change =< -1.5
Related gene sets (show 1 additional gene sets from the source publication)

(show 99 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by John Newman (University of Washington)
Source platform AFFY_HG_U95
Dataset references (show 1 datasets)
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 153 genes
Gene families Categorize these 153 genes by gene family
Show members (show 180 members mapped to 153 genes)
Version history 3.0: Renamed from AGEING_BRAIN_DN

See MSigDB license terms here. Please note that certain gene sets have special access terms.