Gene Set: LU_AGING_BRAIN_UP

Standard name LU_AGING_BRAIN_UP
Systematic name M5547
Brief description Age up-regulated genes in the human frontal cortex.
Full description or abstract The ageing of the human brain is a cause of cognitive decline in the elderly and the major risk factor for Alzheimer's disease. The time in life when brain ageing begins is undefined. Here we show that transcriptional profiling of the human frontal cortex from individuals ranging from 26 to 106 years of age defines a set of genes with reduced expression after age 40. These genes play central roles in synaptic plasticity, vesicular transport and mitochondrial function. This is followed by induction of stress response, antioxidant and DNA repair genes. DNA damage is markedly increased in the promoters of genes with reduced expression in the aged cortex. Moreover, these gene promoters are selectively damaged by oxidative stress in cultured human neurons, and show reduced base-excision DNA repair. Thus, DNA damage may reduce the expression of selectively vulnerable genes involved in learning, memory and neuronal survival, initiating a programme of brain ageing that starts early in adult life.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15190254   Authors: Lu T,Pan Y,Kao SY,Li C,Kohane I,Chan J,Yankner BA
Exact source Table 2S: Fold change >= 1.5
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Organism Homo sapiens
Contributed by John Newman (University of Washington)
Source platform AFFY_HG_U95
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Version history 3.0: Renamed from AGEING_BRAIN_UP

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