Gene Set: LY_AGING_PREMATURE_DN

Standard name LY_AGING_PREMATURE_DN
Systematic name M1491
Brief description Genes down-regulated in fibroblasts from patients with Hutchinson-Gilford progeria (premature aging), compared to those from normal young individuals.
Full description or abstract Messenger RNA levels were measured in actively dividing fibroblasts isolated from young, middle-age, and old-age humans and humans with progeria, a rare genetic disorder characterized by accelerated aging. Genes whose expression is associated with age-related phenotypes and diseases were identified. The data also suggest that an underlying mechanism of the aging process involves increasing errors in the mitotic machinery of dividing cells in the postreproductive stage of life. We propose that this dysfunction leads to chromosomal pathologies that result in misregulation of genes involved in the aging process.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 10741968   Authors: Ly DH,Lockhart DJ,Lerner RA,Schultz PG
Exact source Table 1, 2: Progeria: FoldD < 0
Related gene sets (show 4 additional gene sets from the source publication)

(show 16 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform AFFY_HuGene
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Version history 3.0: Renamed from HG_PROGERIA_DN

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