Gene Set: MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_UP

Standard name MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_UP
Systematic name M5681
Brief description Genes up-regulated in apoptotic tissues (neuroepithelium) after MDM4 [GeneID=4194] knockout.
Full description or abstract The p53 tumour suppressor functions as a transcriptional activator, and several p53-inducible genes that play a critical proapoptotic role have been described. Moreover, p53 regulates the expression of various proteins participating in autoregulatory feedback loops, including proteins that negatively control p53 stability (Mdm2 and Pirh2) or modulate stress-induced phosphorylation of p53 on Ser-46 (p53DINP1 or Wip1), a key event for p53-induced apoptosis. Here, we describe a new systematic analysis of p53 targets using oligonucleotide chips, and report the identification of dapk1 as a novel p53 target. We demonstrate that dapk1 mRNA levels increase in a p53-dependent manner in various cellular settings. Both human and mouse dapk1 genomic loci contain DNA sequences that bind p53 in vitro and in vivo. Since dapk1 encodes a serine/threonine kinase previously shown to suppress oncogene-induced transformation by activating a p19ARF/p53-dependent apoptotic checkpoint, our results suggest that Dapk1 participates in a new positive feedback loop controlling p53 activation and apoptosis.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15608685   Authors: Martoriati A,Doumont G,Alcalay M,Bellefroid E,Pelicci PG,Marine JC
Exact source Table 1S: Neur = I
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(show 12 gene sets from the same authors)
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Organism Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform AFFY_MG_U74
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Version history 3.0: First introduced

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