Gene Set: MA_PITUITARY_FETAL_VS_ADULT_UP

Standard name MA_PITUITARY_FETAL_VS_ADULT_UP
Systematic name M7250
Brief description Up-regulated in human fetal pituitary tissue, compared to adult pituitary tissue
Full description or abstract Pituitary, a master gland of neuroendocrine system, secretes hormones that orchestrate many physiological processes, under the regulation of multiple signaling pathways. To investigate the genes involved in hormones expression of human pituitary, homemade cDNA microarray containing 14,800 human genes/ESTs were used to profile the gene expression in both fetal and adult pituitaries. Seven hundred and twelve known genes changed over 2-fold between the both tissues. Of which, 23 genes were changed with hormones expression in aging were confirmed by RT-PCR, not only the known regulators such as Pit1, GATA4, ESRRA, GABA-A, and EMK, but also LOC55884, DUSP3, PNN, and RCL, which had not been reported to be involved in the hormones expression. Correspondingly, the mRNAs of GH, PRL, POMC, TSH-beta, FSH-beta, and LH-beta, was increased as much as 6- to 20-fold in adult pituitary than those in fetal pituitary, by real-time quantitative RT-PCR assay. In addition, the mRNAs of signaling pathways, such as cAMP-PKA-CREB, PI3K-Akt, and PKA-ERK were further investigated. Of them, it was only cAMP-PKA-CREB pathway, but not PI3K-Akt and PKA-ERK have the same expressing pattern as hormones. It suggested that cDNA microarray is highly advantages to profile the differential expressed genes that were involved in hormones expression of human pituitary, but it might ignore some responding proteins regulated posttranscriptionally.
Collection ARCHIVED: Archived Founder gene sets that are referenced by current Hallmarks
      C2_CGP: Archived chemical and genetic perturbations
Source publication Pubmed 15894316   Authors: Ma YY,Qi XF,Song SJ,Zhao ZY,Zhu ZD,Qi J,Zhang X,Xiao HS,Teng Y,Han ZG
Exact source Table 1
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Organism Homo sapiens
Contributed by John Newman (University of Washington)
Source platform UniGene_ID
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