Gene Set: MEK_UP.V1_UP

Standard name MEK_UP.V1_UP
Systematic name M2725
Brief description Genes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 [GeneID=2099] MCF-7 cells (breast cancer) stably over-expressing constitutively active MAP2K1 [GeneID=5604] gene.
Full description or abstract Profiling of MCF-7 cell lines stably overexpressing constitutively active MEK as a model of overexpressed growth factor signaling, as well as control vector transfected cells (coMCF-7).
Collection C6: oncogenic signature gene sets
Source publication Pubmed 16585219   Authors: Creighton CJ,Hilger AM,Murthy S,Rae JM,Chinnaiyan AM,El-Ashry D
Exact source MEK vs Controls; top 200 genes (diff. of means)
Related gene sets (show 9 additional gene sets from the source publication)

(show 26 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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