Systematic name M9032
Brief description Down-regulated in MCF7 cells (breast cancer) by HOXA1 [GeneID=3198].
Full description or abstract Expression of homeobox A1 (HOXA1) results in oncogenic transformation of immortalized human mammary epithelial cells with aggressive tumor formation in vivo. However, the mechanisms by which HOXA1 mediates oncogenic transformation is not well defined. To identify molecules that could potentially be involved in HOXA1-mediated oncogenic transformation, microarray analysis was utilized to characterize and compare the gene expression pattern in response to forced expression or depletion of HOXA1 in human mammary carcinoma cells. Gene expression profiling identified that genes involved in the p44/42 mitogen-activated protein (MAP) kinase activation pathway (GRB2, MAP kinase kinase (MEK1) and SDFR1) or p44/42 MAP kinase-regulated genes (IER3, EPAS1, PCNA and catalase) are downstream expression targets of HOXA1. Forced expression of HOXA1 increased GRB2 and MEK1 mRNA and protein expression and increased p44/42 MAP kinase phosphorylation, activity and Elk-1-mediated transcription. Use of a MEK1 inhibitor demonstrated that increased p44/42 MAP kinase activity is required for the HOXA1-mediated increase in cell proliferation, survival, oncogenicity and oncogenic transformation. Thus, modulation of the p44/42 MAP kinase pathway is one mechanism by which HOXA1 mediates oncogenic transformation of the human mammary epithelial cell.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 17213808   Authors: Mohankumar KM,Xu XQ,Zhu T,Kannan N,Miller LD,Liu ET,Gluckman PD,Sukumar S,Emerald BS,Lobie PE
Exact source Table 3S
Related gene sets (show 1 additional gene sets from the source publication)

(show 16 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 173 genes
Gene families Categorize these 173 genes by gene family
Show members (show 203 members mapped to 173 genes)
Version history 6.2: Renamed from MOHANKUMAR_TLX1_TARGETS_DN

See MSigDB license terms here. Please note that certain gene sets have special access terms.