Gene Set: MTOR_UP.N4.V1_DN

Standard name MTOR_UP.N4.V1_DN
Systematic name M2756
Brief description Genes down-regulated in CEM-C1 cells (T-CLL) in comparison of control vs rapamycin (sirolimus) [PubChem=6610346], an mTOR pathway inhibitor.
Full description or abstract CEM-C1 cells were treated with 10 nM rapamycin or DMSO and harvested for microarray analysis at 24 hours
Collection C6: oncogenic signature gene sets
Source publication Pubmed 17010674   Authors: Wei G,Twomey D,Lamb J,Schlis K,Agarwal J,Stam RW,Opferman JT,Sallan SE,den Boer ML,Pieters R,Golub TR,Armstrong SA
Exact source contol (DMSO) vs 24h of rapamycin treatment; bottom 200 genes (diff. of means)
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(show 304 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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Global Cancer Map (Broad Institute)
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