Human Gene Set: NAKAJIMA_EOSINOPHIL


Standard name NAKAJIMA_EOSINOPHIL
Systematic name M8344
Brief description Top 30 increased eosinophil specific transcripts.
Full description or abstract Mast cells (MCs) and eosinophils are thought to play important roles in evoking allergic inflammation. Cell-type--specific gene expression was screened among 12,000 genes in human MCs and eosinophils with the use of high-density oligonucleotide probe arrays. In comparison with other leukocytes, MCs expressed 140 cell-type--specific transcripts, whereas eosinophils expressed only 34. Among the transcripts for expected MC-specific proteins such as tryptase, major basic protein (MBP), which had been thought to be eosinophil specific, was ranked fourth in terms of amounts of increased MC-specific messenger RNA. Mature eosinophils were almost lacking this transcript. MCs obtained from 4 different sources (ie, lung, skin, adult peripheral blood progenitor--derived and cord blood progenitor--derived MCs, and eosinophils) were found to have high protein levels of MBP in their granules with the use of flow cytometric and confocal laser scanning microscopic analyses. The present finding that MCs can produce abundant MBP is crucial because many reports regarding allergic pathogenesis have been based on earlier findings that MBP was almost unique to eosinophils and not produced by MCs. (Blood. 2001;98:1127-1134)
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11493461   Authors: Nakajima T,Matsumoto K,Suto H,Tanaka K,Ebisawa M,Tomita H,Yuki K,Katsunuma T,Akasawa A,Hashida R,Sugita Y,Ogawa H,Ra C,Saito H
Exact source Table 2
Related gene sets (show 1 additional gene sets from the source publication)

(show 7 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform or
identifier namespace		 HUMAN_SEQ_ACCESSION
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 25 genes
Gene families ? Categorize these 25 genes by gene family
Show members (show 30 source identifiers mapped to 25 genes)
Version history 3.0: Renamed from NAKAJIMA_MCSMBP_EOS

See MSigDB license terms here. Please note that certain gene sets have special access terms.