Gene Set: NELSON_RESPONSE_TO_ANDROGEN_DN

Standard name NELSON_RESPONSE_TO_ANDROGEN_DN
Systematic name M16830
Brief description Genes down-regulated in LNCaP cells (prostate cancer) in response to synthetic androgen R1881 [PubChem=13766].
Full description or abstract The human prostate gland is an important target organ of androgenic hormones. Testosterone and dihydrotestosterone interact with the androgen receptor to regulate vital aspects of prostate growth and function including cellular proliferation, differentiation, apoptosis, metabolism, and secretory activity. Our objective in this study was to characterize the temporal program of transcription that reflects the cellular response to androgens and to identify specific androgen-regulated genes (ARGs) or gene networks that participate in these responses. We used cDNA microarrays representing about 20,000 distinct human genes to profile androgen-responsive transcripts in the LNCaP adenocarcinoma cell line and identified 146 genes with transcript alterations more than 3-fold. Of these, 103 encode proteins with described functional roles, and 43 represent transcripts that have yet to be characterized. Temporal gene expression profiles grouped the ARGs into four distinct cohorts. Five uncharacterized ARGs demonstrated exclusive or high expression levels in the prostate relative to other tissues studied. A search of available DNA sequence upstream of 28 ARGs identified 25 with homology to the androgen response-element consensus-binding motif. These results identify previously uncharacterized and unsuspected genes whose expression levels are directly or indirectly regulated by androgens; further, they provide a comprehensive temporal view of the transcriptional program of human androgen-responsive cells.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12185249   Authors: Nelson PS,Clegg N,Arnold H,Ferguson C,Bonham M,White J,Hood L,Lin B
Exact source Table 1S
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(show 6 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Pablo Tamayo (MSigDB Team)
Source platform Human_RefSeq
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Version history 3.0: Renamed from NELSON_ANDROGEN_DN

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