Gene Set: P53_DN.V1_DN

Standard name P53_DN.V1_DN
Systematic name M2697
Brief description Genes down-regulated in NCI-60 panel of cell lines with mutated TP53 [GeneID=7157].
Full description or abstract We examined gene expression patterns from the NCI-60 collection of cancer cell lines. We sought to use these data to identify targets of the transcription factor p53, which regulates gene expression in response to various signals of cellular stress. The mutational status of the p53 gene has been reported for 50 of the NCI-60 cell lines, with 17 being classified as normal and 33 as carrying mutations in the gene.
Collection C6: oncogenic signature gene sets
Source publication Pubmed 16199517   Authors: Subramanian A,Tamayo P,Mootha VK,Mukherjee S,Ebert BL,Gillette MA,Paulovich A,Pomeroy SL,Golub TR,Lander ES,Mesirov JP
Exact source p53 mutant vs wt panel of NCI-60 cell lines; bottom 200 genes (diff. of means)
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Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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