Gene Set: PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTIC_PLAQUE_DN

Standard name PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTIC_PLAQUE_DN
Systematic name M12432
Brief description Genes down-regulated in unstable ateroslerotic plaques compared to the stable ones.
Full description or abstract OBJECTIVE: Comparison of gene expression in stable versus unstable atherosclerotic plaque may be confounded by interpatient variability. The aim of this study was to identify differences in gene expression between stable and unstable segments of plaque obtained from the same patient. METHODS AND RESULTS: Human carotid endarterectomy specimens were segmented and macroscopically classified using a morphological classification system. Two analytical methods, an intraplaque and an interplaque analysis, revealed 170 and 1916 differentially expressed genes, respectively using Affymetrix gene chip analysis. A total of 115 genes were identified from both analyses. The differential expression of 27 genes was also confirmed using quantitative-polymerase chain reaction on a larger panel of samples. Eighteen of these genes have not been associated previously with plaque instability, including the metalloproteinase, ADAMDEC1 (approximately 37-fold), retinoic acid receptor responder-1 (approximately 5-fold), and cysteine protease legumain (approximately 3-fold). Matrix metalloproteinase-9 (MMP-9), cathepsin B, and a novel gene, legumain, a potential activator of MMPs and cathepsins, were also confirmed at the protein level. CONCLUSIONS: The differential expression of 18 genes not previously associated with plaque rupture has been confirmed in stable and unstable regions of the same atherosclerotic plaque. These genes may represent novel targets for the treatment of unstable plaque or useful diagnostic markers of plaque instability.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 16741146   Authors: Papaspyridonos M,Smith A,Burnand KG,Taylor P,Padayachee S,Suckling KE,James CH,Greaves DR,Patel L
Exact source Table 4S: Fold change > 0
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Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform AFFY_HG_U133
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Version history 3.0: First introduced

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