Gene Set: PATIL_LIVER_CANCER

Standard name PATIL_LIVER_CANCER
Systematic name M1195
Brief description Genes up-regulated in hepatocellular carcinoma (HCC) compared to normal liver samples.
Full description or abstract Hepatocellular carcinoma (HCC) is one of the major causes of cancer deaths worldwide. New diagnostic and therapeutic options are needed for more effective and early detection and treatment of this malignancy. We identified 703 genes that are highly expressed in HCC using DNA microarrays, and further characterized them in order to uncover novel tumor markers, oncogenes, and therapeutic targets for HCC. Using Gene Ontology annotations, genes with functions related to cell proliferation and cell cycle, chromatin, repair, and transcription were found to be significantly enriched in this list of highly expressed genes. We also identified a set of genes that encode secreted (e.g. GPC3, LCN2, and DKK1) or membrane-bound proteins (e.g. GPC3, IGSF1, and PSK-1), which may be attractive candidates for the diagnosis of HCC. A significant enrichment of genes highly expressed in HCC was found on chromosomes 1q, 6p, 8q, and 20q, and we also identified chromosomal clusters of genes highly expressed in HCC. The microarray analyses were validated by RT-PCR and PCR. This approach of integrating other biological information with gene expression in the analysis helps select aberrantly expressed genes in HCC that may be further studied for their diagnostic or therapeutic utility.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15735714   Authors: Patil MA,Chua MS,Pan KH,Lin R,Lih CJ,Cheung ST,Ho C,Li R,Fan ST,Cohen SN,Chen X,So S
Exact source Suppl. file 4
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Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform HUMAN_SEQ_ACCESSION
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Version history 3.1: First introduced

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