Gene Set: PDGF_UP.V1_DN

Standard name PDGF_UP.V1_DN
Systematic name M2832
Brief description Genes down-regulated in SH-SY5Y cells (neuroblastoma) in response to PDGF [Gene ID=] stimulation.
Full description or abstract To define ERK/PDGFR activation signature, SH-SY5Y cells were grown to confluence and starved overnight in serum-free medium in order to silence any sustained effects from growth factor signaling. Prior to induction with 50ng/ml PDGF, cells were treated with pathway inhibitors 74 mM Apigenin or 50 mM U0126, or with DMSO (carrier) for 60 minutes. Total RNA was isolated 30 minutes after PDGF addition. Experiments were performed in duplicate. The RNA was processed and hybridized with Affymetrix U133A GeneChips.
Collection C6: oncogenic signature gene sets
Source publication Pubmed 18312689   Authors: Antipova AA,Stockwell BR,Golub TR
Exact source PDGF stimulation vs Controls; bottom 300 genes (diff. of means)
Related gene sets (show 3 additional gene sets from the source publication)

(show 250 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 135 genes
Gene families Categorize these 135 genes by gene family
Show members (show 150 members mapped to 135 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.