Human Gene Set: PTEN_DN.V1_DN


Standard name PTEN_DN.V1_DN
Systematic name M2786
Brief description Genes down-regulated upon knockdown of PTEN [GeneID=5728] by RNAi.
Full description or abstract A431, HCC827 and SKBR-3 cells were retrovirally and stably transduced with a small hairpin RNA targeting human PTEN. PTEN knockdown was confirmed at the protein level by western blot to be approximately 90%. PTEN-deficient sublines were named by adding the suffix PR(for PTEN RNAi) at the end of each of the parental cell line names. For example, PTEN deficient A431 cells are called A431-PR. RNA was extracted from each of the parental and PTEN-deificient lines. Each sample was done in duplicate (ie two chips per sample) for a total of twelve samples.
Collection C6: Oncogenic Signature
Source publication Pubmed 17560336   Authors: Vivanco I,Palaskas N,Tran C,Finn SP,Getz G,Kennedy NJ,Jiao J,Rose J,Xie W,Loda M,Golub T,Mellinghoff IK,Davis RJ,Wu H,Sawyers CL
Exact source PTEN ko vs control; bottom 200 genes (diff. of means)
Related gene sets (show 1 additional gene sets from the source publication)

(show 81 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 184 genes
Gene families ? Categorize these 184 genes by gene family
Show members (show 200 source identifiers mapped to 184 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.