Gene Set: PTEN_DN.V1_UP

Standard name PTEN_DN.V1_UP
Systematic name M2787
Brief description Genes up-regulated upon knockdown of PTEN [GeneID=5728] by RNAi.
Full description or abstract A431, HCC827 and SKBR-3 cells were retrovirally and stably transduced with a small hairpin RNA targeting human PTEN. PTEN knockdown was confirmed at the protein level by western blot to be approximately 90%. PTEN-deficient sublines were named by adding the suffix PR(for PTEN RNAi) at the end of each of the parental cell line names. For example, PTEN deficient A431 cells are called A431-PR. RNA was extracted from each of the parental and PTEN-deificient lines. Each sample was done in duplicate (ie two chips per sample) for a total of twelve samples.
Collection C6: oncogenic signature gene sets
Source publication Pubmed 17560336   Authors: Vivanco I,Palaskas N,Tran C,Finn SP,Getz G,Kennedy NJ,Jiao J,Rose J,Xie W,Loda M,Golub T,Mellinghoff IK,Davis RJ,Wu H,Sawyers CL
Exact source PTEN ko vs control; top 200 genes (diff. of means)
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(show 77 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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