Gene Set: PTEN_DN.V2_DN

Standard name PTEN_DN.V2_DN
Systematic name M2758
Brief description Genes down-regulated in HCT116 cells (colon carcinoma) upon knockdown of PTEN [GeneID=5728] by RNAi.
Full description or abstract Two HCT116 PTEN+/+ cell lines (parental cells and a clone with random integration of the targeting vector) and three independently-derived HCT116 PTEN-/- cell lines were studied
Collection C6: oncogenic signature gene sets
Source publication Pubmed 17060456   Authors: Kim JS,Lee C,Bonifant CL,Ressom H,Waldman T
Exact source PTEN ko vs control; bottom 300 genes (diff. of means)
Related gene sets (show 3 additional gene sets from the source publication)

(show 16 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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