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Systematic name M18811
Brief description Genes constituting the XPRSS-Int network: intersection of genes whose expression correlates with BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200] in a compendium of normal tissues.
Full description or abstract Many cancer-associated genes remain to be identified to clarify the underlying molecular mechanisms of cancer susceptibility and progression. Better understanding is also required of how mutations in cancer genes affect their products in the context of complex cellular networks. Here we have used a network modeling strategy to identify genes potentially associated with higher risk of breast cancer. Starting with four known genes encoding tumor suppressors of breast cancer, we combined gene expression profiling with functional genomic and proteomic (or 'omic') data from various species to generate a network containing 118 genes linked by 866 potential functional associations. This network shows higher connectivity than expected by chance, suggesting that its components function in biologically related pathways. One of the components of the network is HMMR, encoding a centrosome subunit, for which we demonstrate previously unknown functional associations with the breast cancer-associated gene BRCA1. Two case-control studies of incident breast cancer indicate that the HMMR locus is associated with higher risk of breast cancer in humans. Our network modeling strategy should be useful for the discovery of additional cancer-associated genes.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17922014   Authors: Pujana MA,Han JD,Starita LM,Stevens KN,Tewari M,Ahn JS,Rennert G,Moreno V,Kirchhoff T,Gold B,Assmann V,Elshamy WM,Rual JF,Levine D,Rozek LS,Gelman RS,Gunsalus KC,Greenberg RA,Sobhian B,Bertin N,Venkatesan K,Ayivi-Guedehoussou N,Solé X,Hernández P,Lázaro C,Nathanson KL,Weber BL,Cusick ME,Hill DE,Offit K,Livingston DM,Gruber SB,Parvin JD,Vidal M
Exact source Table 2S: XPRSS-Int
Related gene sets (show 8 additional gene sets from the source publication)

(show 105 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Leona Saunders (MSigDB Team)
Source platform Human_NCBI_Gene_ID
Dataset references (show 1 datasets)
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: First introduced

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