Gene Set: RAHMAN_TP53_TARGETS_PHOSPHORYLATED

Standard name RAHMAN_TP53_TARGETS_PHOSPHORYLATED
Systematic name M1333
Brief description Proteins phosporylated in HCT116 cells (colon cancer) upon p53 [GeneID=7157] activation.
Full description or abstract The p53 tumor suppressor regulates transcription of target genes. We have previously analysed the p53-dependent proteome and identified novel protein targets. Here we have examined p53-dependent phosphorylation using two-dimensional gel electrophoresis and staining with the fluorescent phosphoprotein dye Pro-Q Diamond. We report that p53 induces phosphorylation of a subset of proteins including Nm23, DJ-1, ANXA1 and PrxII. Our identification of p53-dependent phosphorylation of specific target proteins reveals new aspects of the p53-dependent cellular response and suggests that such posttranslational modifications may contribute to p53-mediated tumor suppression.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18438429   Authors: Rahman-Roblick R,Hellman U,Becker S,Bader FG,Auer G,Wiman KG,Roblick UJ
Exact source Table 1
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Organism Homo sapiens
Contributed by Jessica Robertson (MSigDB Team)
Source platform HUMAN_GENE_SYMBOL
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Version history 3.1: First introduced

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