Gene Set: SCHRAETS_MLL_TARGETS_UP

Standard name SCHRAETS_MLL_TARGETS_UP
Systematic name M1902
Brief description Genes up-regulated in fibroblasts from MLL [GeneID=4297] knockout mice.
Full description or abstract The human mixed lineage leukemia (MLL) gene is involved in about 50 different chromosomal translocations, associated with the disease phenotype of acute leukemia. However, the normal function of MLL is less understood. Homozygous knockouts of murine Mll were embryonal lethal, while heterozygous disruption led to aberrant hox gene expression associated with skeletal malformations, growth retardation, and impaired hematopoiesis. To understand MLL functions on the molecular level, gene expression profiling experiments were performed with a pair of murine cell lines (MLL(+/+) and MLL(-/-)). Microarray hybridization experiments revealed 197 potential target genes that are differentially expressed, providing new and important clues about MLL functions.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12789274   Authors: Schraets D,Lehmann T,Dingermann T,Marschalek R
Exact source Table 1
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(show 14 gene sets from the same authors)
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Organism Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform MOUSE_SEQ_ACCESSION
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Version history 3.1: First introduced

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